Ontology highlight
ABSTRACT:
SUBMITTER: Jang KP
PROVIDER: S-EPMC3951019 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20131217 1
A highly selective NHC-catalyzed synthesis of γ-butyrolactones from the fusion of enals and α-ketophosphonates has been developed. Computational modeling of competing transition states guided a rational design strategy to achieve enhanced levels of enantioselectivity with a new tailored C1-symmetric biaryl-saturated imidazolium-derived NHC catalyst. ...[more]