Abatacept in B7-1-positive proteinuric kidney disease.

ABSTRACT: Abatacept (cytotoxic T-lymphocyte-associated antigen 4-immunoglobulin fusion protein [CTLA-4-Ig]) is a costimulatory inhibitor that targets B7-1 (CD80). The present report describes five patients who had focal segmental glomerulosclerosis (FSGS) (four with recurrent FSGS after transplantation and one with primary FSGS) and proteinuria with B7-1 immunostaining of podocytes in kidney-biopsy specimens. Abatacept induced partial or complete remissions of proteinuria in these patients, suggesting that B7-1 may be a useful biomarker for the treatment of some glomerulopathies. Our data indicate that abatacept may stabilize ?1-integrin activation in podocytes and reduce proteinuria in patients with B7-1-positive glomerular disease.

SUBMITTER: Yu CC 

PROVIDER: S-EPMC3951406 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature