Ontology highlight
ABSTRACT:
SUBMITTER: Iida A
PROVIDER: S-EPMC3956141 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Iida Atsumi A Iwagawa Toshiro T Kuribayashi Hiroshi H Satoh Shinya S Mochizuki Yujin Y Baba Yukihiro Y Nakauchi Hiromitsu H Furukawa Takahisa T Koseki Haruhiko H Murakami Akira A Watanabe Sumiko S
Proceedings of the National Academy of Sciences of the United States of America 20140226 10
Di- and trimethylation of lysine 27 on histone H3 (H3K27me2/3) is an important gene repression mechanism. H3K27me2/3-specific demethylase, Jmjd3, was expressed in the inner nuclear layer during late retinal development. In contrast, H3K27 methyltransferase, Ezh2, was highly expressed in the embryonic retina but its expression decreased rapidly after birth. Jmjd3 loss of function in the developing retina resulted in failed differentiation of PKC-positive bipolar cell subsets (rod-ON-BP) and reduc ...[more]