Ontology highlight
ABSTRACT:
SUBMITTER: Schmidt-Edelkraut U
PROVIDER: S-EPMC3958027 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Molecular and cellular biology 20140106 6
Imprinted genes play a critical role in brain development and mental health, although the underlying molecular and cellular mechanisms remain incompletely understood. The family of basic helix-loop-helix (bHLH) proteins directs the proliferation, differentiation, and specification of distinct neuronal progenitor populations. Here, we identified the bHLH factor gene Tcf4 as a direct target gene of Zac1/Plagl1, a maternally imprinted transcriptional regulator, during early neurogenesis. Zac1 and T ...[more]