Enzymology of RNA cap synthesis.
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ABSTRACT:
SUBMITTER: Ghosh A
PROVIDER: S-EPMC3962952 | biostudies-literature | 2010 Jul-Aug
REPOSITORIES: biostudies-literature
Publications
Enzymology of RNA cap synthesis.
Ghosh Agnidipta A Lima Christopher D CD
Wiley interdisciplinary reviews. RNA 20100525 1
The 5' guanine-N7 methyl cap is unique to cellular and viral messenger RNA (mRNA) and is the first co-transcriptional modification of mRNA. The mRNA cap plays a pivotal role in mRNA biogenesis and stability, and is essential for efficient splicing, mRNA export, and translation. Capping occurs by a series of three enzymatic reactions that results in formation of N7-methyl guanosine linked through a 5'-5' inverted triphosphate bridge to the first nucleotide of a nascent transcript. Capping of cell ...[more]
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