Ontology highlight
ABSTRACT:
SUBMITTER: Leiter J
PROVIDER: S-EPMC7004131 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Leiter Josef J Reichert Dennis D Rentmeister Andrea A Micura Ronald R
Chembiochem : a European journal of chemical biology 20191108 1-2
Eukaryotic mRNAs possess 5' caps that are determinants for their function. A structural characteristic of 5' caps is methylation, with this feature already present in early eukaryotes such as Trypanosoma. While the common cap-0 (m<sup>7</sup> GpppN) shows a rather simple methylation pattern, the Trypanosoma cap-4 displays seven distinguished additional methylations within the first four nucleotides. The study of essential biological functions mediated by these unique structural features of the c ...[more]