Ontology highlight
ABSTRACT:
SUBMITTER: Zahn A
PROVIDER: S-EPMC3964074 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Zahn Astrid A Eranki Anil K AK Patenaude Anne-Marie AM Methot Stephen P SP Fifield Heather H Cortizas Elena M EM Foster Paul P Imai Kohsuke K Durandy Anne A Larijani Mani M Verdun Ramiro E RE Di Noia Javier M JM
Proceedings of the National Academy of Sciences of the United States of America 20140303 11
Activation-induced deaminase (AID) triggers antibody class switch recombination (CSR) in B cells by initiating DNA double strand breaks that are repaired by nonhomologous end-joining pathways. A role for AID at the repair step is unclear. We show that specific inactivation of the C-terminal AID domain encoded by exon 5 (E5) allows very efficient deamination of the AID target regions but greatly impacts the efficiency and quality of subsequent DNA repair. Specifically eliminating E5 not only prec ...[more]