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The cytokine IL-22 promotes pathogen colonization by suppressing related commensal bacteria.


ABSTRACT: Interleukin-22 (IL-22) is highly induced in response to infections with a variety of pathogens, and its main functions are considered to be tissue repair and host defense at mucosal surfaces. Here we showed that IL-22 has a unique role during infection in that its expression suppressed the intestinal microbiota and enhanced the colonization of a pathogen. IL-22 induced the expression of antimicrobial proteins, including lipocalin-2 and calprotectin, which sequester essential metal ions from microbes. Because Salmonella enterica ser. Typhimurium can overcome metal ion starvation mediated by lipocalin-2 and calprotectin via alternative pathways, IL-22 boosted its colonization of the inflamed intestine by suppressing commensal Enterobacteriaceae, which are susceptible to the antimicrobial proteins. Thus, IL-22 tipped the balance between pathogenic and commensal bacteria in favor of a pathogen. Taken together, IL-22 induction can be exploited by pathogens to suppress the growth of their closest competitors, thereby enhancing pathogen colonization of mucosal surfaces.

SUBMITTER: Behnsen J 

PROVIDER: S-EPMC3964146 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

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The cytokine IL-22 promotes pathogen colonization by suppressing related commensal bacteria.

Behnsen Judith J   Jellbauer Stefan S   Wong Christina P CP   Edwards Robert A RA   George Michael D MD   Ouyang Wenjun W   Raffatellu Manuela M  

Immunity 20140206 2


Interleukin-22 (IL-22) is highly induced in response to infections with a variety of pathogens, and its main functions are considered to be tissue repair and host defense at mucosal surfaces. Here we showed that IL-22 has a unique role during infection in that its expression suppressed the intestinal microbiota and enhanced the colonization of a pathogen. IL-22 induced the expression of antimicrobial proteins, including lipocalin-2 and calprotectin, which sequester essential metal ions from micr  ...[more]

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