Unknown

Dataset Information

0

Comparative analysis of the macroscale structural connectivity in the macaque and human brain.


ABSTRACT: The macaque brain serves as a model for the human brain, but its suitability is challenged by unique human features, including connectivity reconfigurations, which emerged during primate evolution. We perform a quantitative comparative analysis of the whole brain macroscale structural connectivity of the two species. Our findings suggest that the human and macaque brain as a whole are similarly wired. A region-wise analysis reveals many interspecies similarities of connectivity patterns, but also lack thereof, primarily involving cingulate regions. We unravel a common structural backbone in both species involving a highly overlapping set of regions. This structural backbone, important for mediating information across the brain, seems to constitute a feature of the primate brain persevering evolution. Our findings illustrate novel evolutionary aspects at the macroscale connectivity level and offer a quantitative translational bridge between macaque and human research.

SUBMITTER: Goulas A 

PROVIDER: S-EPMC3967942 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC9980133 | biostudies-literature
| S-EPMC6867501 | biostudies-literature
| S-EPMC11252401 | biostudies-literature
| S-EPMC10646692 | biostudies-literature
| S-EPMC11185649 | biostudies-literature
| S-EPMC9363436 | biostudies-literature
| S-EPMC5111767 | biostudies-literature
| S-EPMC7065875 | biostudies-literature
| S-EPMC6157013 | biostudies-literature
| S-EPMC6909781 | biostudies-literature