Ontology highlight
ABSTRACT:
SUBMITTER: Huang F
PROVIDER: S-EPMC3968024 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Huang FengFei F Ben Aissa Manel M Magron Audrey A Huard Caroline C CC Godin Chantal C Lévesque Georges G Carreau Madeleine M
PloS one 20140327 3
The Fanconi anemia group C protein (FANCC) is one of the several proteins that comprise the Fanconi anemia (FA) network involved in genomic surveillance. FANCC is mainly cytoplasmic and has many functions, including apoptosis suppression through caspase-mediated proteolytic processing. Here, we examined the role of FANCC proteolytic fragments by identifying their binding partners. We performed a yeast two-hybrid screen with caspase-mediated FANCC cleavage products and identified the dependence r ...[more]