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Formation of targeted monovalent quantum dots by steric exclusion.

ABSTRACT: Precise control over interfacial chemistry between nanoparticles and other materials remains a major challenge that limits broad application of nanotechnology in biology. To address this challenge, we used 'steric exclusion' to completely convert commercial quantum dots (QDs) into monovalent imaging probes by wrapping each QD with a functionalized oligonucleotide. We demonstrated the utility of these QDs as modular and nonperturbing imaging probes by tracking individual Notch receptors on live cells.

SUBMITTER: Farlow J

PROVIDER: S-EPMC3968776 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature

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Formation of targeted monovalent quantum dots by steric exclusion.

Farlow Justin J Seo Daeha D Broaders Kyle E KE Taylor Marcus J MJ Gartner Zev J ZJ Jun Young-Wook YW

Nature methods 20131013 12

Precise control over interfacial chemistry between nanoparticles and other materials remains a major challenge that limits broad application of nanotechnology in biology. To address this challenge, we used 'steric exclusion' to completely convert commercial quantum dots (QDs) into monovalent imaging probes by wrapping each QD with a functionalized oligonucleotide. We demonstrated the utility of these QDs as modular and nonperturbing imaging probes by tracking individual Notch receptors on live c ...[more]

PMID: 24122039

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