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Balticolid: a new 12-membered macrolide with antiviral activity from an ascomycetous fungus of marine origin.

ABSTRACT: A new 12-membered macrolide, balticolid (1) was isolated from the EtOAc extract of the culture broth of fungal strain 222 belonging to the Ascomycota, which was found on driftwood collected from the coast of the Greifswalder Bodden, Baltic Sea, Germany. The structure of balticolid was determined to be (3R,11R), (4E,8E)-3-hydroxy-11-methyloxacyclododeca-4,8-diene-1,7-dione using extensive spectral data as well as the modified Mosher ester method. Balticolid (1) displayed anti-HSV-1 activity with an IC?? value of 0.45 ?M.

SUBMITTER: Shushni MA

PROVIDER: S-EPMC3111186 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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Balticolid: a new 12-membered macrolide with antiviral activity from an ascomycetous fungus of marine origin.

Shushni Muftah A M MAM Singh Rajinder R Mentel Renate R Lindequist Ulrike U

Marine drugs 20110513 5

A new 12-membered macrolide, balticolid (1) was isolated from the EtOAc extract of the culture broth of fungal strain 222 belonging to the Ascomycota, which was found on driftwood collected from the coast of the Greifswalder Bodden, Baltic Sea, Germany. The structure of balticolid was determined to be (3R,11R), (4E,8E)-3-hydroxy-11-methyloxacyclododeca-4,8-diene-1,7-dione using extensive spectral data as well as the modified Mosher ester method. Balticolid (1) displayed anti-HSV-1 activity with ...[more]

PMID: 21673893

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