On-resin peptide macrocyclization using thiol-ene click chemistry.
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ABSTRACT:
SUBMITTER: Aimetti AA
PROVIDER: S-EPMC3969419 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Publications
On-resin peptide macrocyclization using thiol-ene click chemistry.
Aimetti Alex A AA Shoemaker Richard K RK Lin Chien-Chi CC Anseth Kristi S KS
Chemical communications (Cambridge, England) 20100408 23
A versatile and rapid synthetic strategy has been developed for the on-resin cyclization of peptides using thiol-ene photochemistry. This unique method exploits the thiol group of natural cysteine amino acids and allows for various alkenes to be incorporated orthogonal to the peptide backbone. ...[more]
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