Ontology highlight
ABSTRACT:
SUBMITTER: Kasprowicz J
PROVIDER: S-EPMC3971740 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Kasprowicz Jaroslaw J Kuenen Sabine S Swerts Jef J Miskiewicz Katarzyna K Verstreken Patrik P
The Journal of cell biology 20140324 7
Dynamin is a well-known regulator of synaptic endocytosis. Temperature-sensitive dynamin (shi(ts1)) mutations in Drosophila melanogaster or deletion of some of the mammalian Dynamins causes the accumulation of invaginated endocytic pits at synapses, sometimes also on bulk endosomes, indicating impaired membrane scission. However, complete loss of dynamin function has not been studied in neurons in vivo, and whether Dynamin acts in different aspects of synaptic vesicle formation remains enigmatic ...[more]