Ontology highlight
ABSTRACT:
SUBMITTER: Ficarro SB
PROVIDER: S-EPMC3971929 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Journal of the American Society for Mass Spectrometry 20140205 4
We assemble a versatile molecular scaffold from simple building blocks to create binary and multiplexed stable isotope reagents for quantitative mass spectrometry. Termed Protected Amine Labels (PAL), these reagents offer multiple analytical figures of merit including, (1) robust targeting of peptide N-termini and lysyl side chains, (2) optimal mass spectrometry ionization efficiency through regeneration of primary amines on labeled peptides, (3) an amino acid-based mass tag that incorporates he ...[more]