Asymmetric palladium-catalyzed directed intermolecular fluoroarylation of styrenes.
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ABSTRACT: A mild catalytic asymmetric direct fluoro-arylation of styrenes has been developed. The palladium-catalyzed three-component coupling of Selectfluor, a styrene and a boronic acid, provides chiral monofluorinated compounds in good yield and in high enantiomeric excess. A mechanism proceeding through a Pd(IV)-fluoride intermediate is proposed for the transformation and synthesis of an sp(3) C-F bond.
SUBMITTER: Talbot EP
PROVIDER: S-EPMC3971964 | biostudies-literature |
REPOSITORIES: biostudies-literature
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