Ontology highlight
ABSTRACT:
SUBMITTER: Yang X
PROVIDER: S-EPMC4558008 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Yang Xu X Chang Hae Ryung HR Yin Y Whitney YW
PloS one 20150902 9
Despite their clear T7-bacteriophage origin, mitochondrial RNA polymerases have evolved to require transcription factors. All mitochondrial polymerases contain an extra N-terminal domain that has no counterpart in the self-proficient phage enzyme, which is therefore hypothesized to interact with transcription factors. We studied a series of N-terminal deletion mutants of yeast mitochondrial RNA polymerase, Rpo41, and have found that the N-terminal region does not abolish the effects of Mtf1; rat ...[more]