Ontology highlight
ABSTRACT:
SUBMITTER: Morozov YI
PROVIDER: S-EPMC3973326 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Morozov Yaroslav I YI Agaronyan Karen K Cheung Alan C M AC Anikin Michael M Cramer Patrick P Temiakov Dmitry D
Nucleic acids research 20140106 6
The mitochondrial genome is transcribed by a single-subunit T7 phage-like RNA polymerase (mtRNAP), structurally unrelated to cellular RNAPs. In higher eukaryotes, mtRNAP requires two transcription factors for efficient initiation-TFAM, a major nucleoid protein, and TFB2M, a transient component of mtRNAP catalytic site. The mechanisms behind assembly of the mitochondrial transcription machinery and its regulation are poorly understood. We isolated and identified a previously unknown human mitocho ...[more]