Ontology highlight
ABSTRACT:
SUBMITTER: Quinlan AR
PROVIDER: S-EPMC3975295 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Quinlan Aaron R AR Boland Michael J MJ Leibowitz Mitchell L ML Shumilina Svetlana S Pehrson Sidney M SM Baldwin Kristin K KK Hall Ira M IM
Cell stem cell 20111001 4
The biomedical utility of induced pluripotent stem cells (iPSCs) will be diminished if most iPSC lines harbor deleterious genetic mutations. Recent microarray studies have shown that human iPSCs carry elevated levels of DNA copy number variation compared with those in embryonic stem cells, suggesting that these and other classes of genomic structural variation (SV), including inversions, smaller duplications and deletions, complex rearrangements, and retroelement transpositions, may frequently a ...[more]