Ontology highlight
ABSTRACT:
SUBMITTER: Choi JH
PROVIDER: S-EPMC3975461 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Choi Jun-Hyeok JH Yu Nam-Kyung NK Baek Gi-Chul GC Bakes Joseph J Seo Daekwan D Nam Hye Jin HJ Baek Sung Hee SH Lim Chae-Seok CS Lee Yong-Seok YS Kaang Bong-Kiun BK
Molecular brain 20140311
Adeno-associated virus (AAV) vectors can deliver transgenes to diverse cell types and are therefore useful for basic research and gene therapy. Although AAV has many advantages over other viral vectors, its relatively small packaging capacity limits its use for delivering large genes. The available transgene size is further limited by the existence of additional elements in the expression cassette without which the gene expression level becomes much lower. By using alternative combinations of sh ...[more]