Ontology highlight
ABSTRACT:
SUBMITTER: Halouska S
PROVIDER: S-EPMC3975674 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Halouska Steven S Fenton Robert J RJ Zinniel Denise K DK Marshall Darrell D DD Barletta Raúl G RG Powers Robert R
Journal of proteome research 20131213 2
d-Cycloserine is an effective second line antibiotic used as a last resort to treat multi (MDR)- and extensively (XDR) drug resistant strains of Mycobacterium tuberculosis . d-Cycloserine interferes with the formation of peptidoglycan biosynthesis by competitive inhibition of alanine racemase (Alr) and d-alanine-d-alanine ligase (Ddl). Although the two enzymes are known to be inhibited, the in vivo lethal target is still unknown. Our NMR metabolomics work has revealed that Ddl is the primary tar ...[more]