Ontology highlight
ABSTRACT:
SUBMITTER: Jang TH
PROVIDER: S-EPMC3976076 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Acta crystallographica. Section F, Structural biology communications 20140325 Pt 4
Transglutaminase 2 (TG2) is a multi-functional protein that has been implicated in a variety of physiological cellular activities, including apoptosis, angiogenesis and cellular differentiation. Two functions of TG2 are protein cross-linking and GTP hydrolysis activities. The protein cross-linking activity of TG2 is positively controlled by calcium; however, the molecular mechanism of its Ca(2+)-dependent activity is completely unknown. In the present study, full-length human TG2 in complex with ...[more]