Ontology highlight
ABSTRACT:
SUBMITTER: Kaliman S
PROVIDER: S-EPMC3976519 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Biophysical journal 20140401 7
It is well established that MDCK II cells grow in circular colonies that densify until contact inhibition takes place. Here, we show that this behavior is only typical for colonies developing on hard substrates and report a new growth phase of MDCK II cells on soft gels. At the onset, the new phase is characterized by small, three-dimensional droplets of cells attached to the substrate. When the contact area between the agglomerate and the substrate becomes sufficiently large, a very dense monol ...[more]