Ontology highlight
ABSTRACT:
SUBMITTER: Guzman GI
PROVIDER: S-EPMC6452873 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Guzmán Gabriela I GI Sandberg Troy E TE LaCroix Ryan A RA Nyerges Ákos Á Papp Henrietta H de Raad Markus M King Zachary A ZA Hefner Ying Y Northen Trent R TR Notebaart Richard A RA Pál Csaba C Palsson Bernhard O BO Papp Balázs B Feist Adam M AM
Molecular systems biology 20190408 4
Evidence suggests that novel enzyme functions evolved from low-level promiscuous activities in ancestral enzymes. Yet, the evolutionary dynamics and physiological mechanisms of how such side activities contribute to systems-level adaptations are not well characterized. Furthermore, it remains untested whether knowledge of an organism's promiscuous reaction set, or underground metabolism, can aid in forecasting the genetic basis of metabolic adaptations. Here, we employ a computational model of u ...[more]