Ontology highlight
ABSTRACT:
SUBMITTER: Peana MF
PROVIDER: S-EPMC3982466 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Peana Massimiliano Francesco MF Medici Serenella S Ledda Alessia A Nurchi Valeria Marina VM Zoroddu Maria Antonietta MA
TheScientificWorldJournal 20140324
P₁D₂E₃K₄H₅E₆L₇ (PK9-H), a fragment of Ypk9, the yeast homologue of the human Park9 protein, was studied for its coordination abilities towards Ni(II) and Cu(II) ions through mono- and bi-dimensional NMR techniques. Both proteins are involved in the transportation of metal ions, including manganese and nickel, from the cytosol to the lysosomal lumen. Ypk9 showed manganese detoxification role, preventing a Mn-induced Parkinsonism (PD) besides mutations in Park9, linked to a juvenile form of the di ...[more]