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Syntheses, crystal structures, magnetic properties and ESI-MS studies of a series of trinuclear Cu^IIM^IICu^II compounds (M = Cu, Ni, Co, Fe, Mn, Zn).

ABSTRACT: Six trinuclear Cu^IIM^IICu^II compounds (M = Cu, Ni, Co, Fe, Mn, Zn) derived from the Schiff base ligand, H₂L (2 + 1 condensation product of salicylaldehyde and trans-1,2-diaminocyclohexane) are reported in this investigation. The composition of the metal complexes are [{Cu^IIL(ClO₄)}₂Cu^II(H₂O)]·2H₂O (1), [{Cu^IIL(ClO₄)}{Ni^II(H₂O)₂}{Cu^IIL}]ClO₄·CH₃COCH₃ (2), [{Cu^IIL(ClO₄)}{Co^II(CH₃COCH₃)(H₂O)}{Cu^IIL(CH₃COCH₃)}]ClO₄ (3) and isomorphic [{Cu^IIL(ClO₄)}₂M^II(CH₃OH)₂] (4, M = Fe; 5, M = Mn; 6, M = Zn). Two copper(ii) ions in 1-6 occupy N₂O₂ compartments of two L^2- ligands, while the second metal ion occupies the O(phenoxo)₄ site provided by the two ligands, i.e., the two metal ions in both Cu^IIM^II pairs are diphenoxo-bridged. Positive ESI-MS of 1-6 reveals some interesting features. Variable-temperature and variable-field magnetic studies reveal moderate or weak antiferromagnetic interactions in 1-6 with the following values of magnetic exchange integrals (H = -2JS ₁ S ₂ type): J ₁ = -136.50 cm^-1 and J = 0.00 for the Cu^IICu^IICu^II compound 1; J ₁ = -22.16 cm^-1 and J = -1.97 cm^-1 for the Cu^IINi^IICu^II compound 2; J ₁ = -14.78 cm^-1 and J = -1.86 cm^-1 for the Cu^IICo^IICu^II compound 3; J ₁ = -6.35 cm^-1 and J = -1.17 cm^-1 for the Cu^IIFe^IICu^II compound 4; J ₁ = -6.02 cm^-1 and J = -1.70 cm^-1 for the Cu^IIMn^IICu^II compound 5; J = -2.25 cm^-1 for the Cu^IIZn^IICu^II compound 6 (J is between two Cu^II in the N₂O₂ compartments; J ₁ is between Cu^II and M^II through a diphenoxo bridge).

SUBMITTER: Hari N

PROVIDER: S-EPMC9078389 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Syntheses, crystal structures, magnetic properties and ESI-MS studies of a series of trinuclear CuIIMIICuII compounds (M = Cu, Ni, Co, Fe, Mn, Zn).

Hari Nairita N Mandal Shuvankar S Jana Arpita A Sparkes Hazel A HA Mohanta Sasankasekhar S

RSC advances 20180214 14

Six trinuclear CuIIMIICuII compounds (M = Cu, Ni, Co, Fe, Mn, Zn) derived from the Schiff base ligand, H2L (2 + 1 condensation product of salicylaldehyde and trans-1,2-diaminocyclohexane) are reported in this investigation. The composition of the metal complexes are [{CuIIL(ClO4)}2CuII(H2O)]·2H2O (1), [{CuIIL(ClO4)}{NiII(H2O)2 ...[more]

PMID: 35539115

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Project description:New Schiff base ligand, derived from antiviral valacyclovir, and its novel Cr(III), Mn(II), Co(II), Ni(II), Cu(II), Zn(II) complexes have been synthesized. By using a variety of analytical and spectroscopic techniques, the type of bonding between the ligand and the metal ions in the recently formed complexes was clarified. The Schiff base ligand act as a bidentate and coordinated with the metal ions through the azomethine-N and the phenolic-O centers, in a mono-deprotonated form. Except for the Zn(II) complex, which displayed a tetrahedral geometry, all complexes displayed octahedral geometry. The TGA findings supported that the stability and decomposition properties of the metal complexes were entirely distinct from one another. The thermogram showed decomposition of all investigated metal complexes above 200 °C in three, four or five steps, and indicated the high thermal stability of these complexes. According to XRD patterns, the particles of these complexes were located at the nanoscale. Moreover, for all the samples analyzed, the TEM images showed uniform and homogeneous surface morphology. The biological activity revealing the high efficiencies of the screened complexes as antibacterial and antitumor agents. The antimicrobial activity of the ligand and its complexes was examined against a variety of pathogenic bacteria and fungi including Escherichia coli, Staphylococcus aureus and Candida albicans. The data obtained revealed that the metal ion in the complexes enhanced the antimicrobial activity compared to the free ligand. The high efficiencies toward S. aureus, E. coli, and C. albicans appeared by Cu(II) complex 23, Ni(II) complex 20, and Ni(II) complex 19, respectively. The antitumor activity of the ligand and its complexes was tested against Hepatocellular carcinoma cell line (HepG-2 cells), the residue 28 which produced after heating the Cu(II) complex 25 at 200 °C for 1 h, exhibited strong inhibition of HepG-2 cell growth. The results of the DNA cleavage investigation demonstrated the ability of investigated Cu(II) complex to degrade DNA. The docking findings showed strong interactions of both the ligand and its examined Cu(II) complex, revealing their ability to cleavage DNA and their potent inhibitory effects on tumor cells. The electrical conductivity study confirmed that the ligand and its investigated complexes had semiconducting properties.

Dataset Information

Syntheses, crystal structures, magnetic properties and ESI-MS studies of a series of trinuclear Cu^IIM^IICu^II compounds (M = Cu, Ni, Co, Fe, Mn, Zn).

Publications

Syntheses, crystal structures, magnetic properties and ESI-MS studies of a series of trinuclear Cu<sup>II</sup>M<sup>II</sup>Cu<sup>II</sup> compounds (M = Cu, Ni, Co, Fe, Mn, Zn).

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