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Ligand-controlled asymmetric arylation of aliphatic ?-amino anion equivalents.

ABSTRACT: A palladium-catalyzed asymmetric arylation of 9-aminofluorene-derived imines using a chiral dialkylbiaryl phosphine as the supporting ligand has been developed. This transformation allows for enantioselective access to a diverse range of ?-branched benzylamines.

SUBMITTER: Zhu Y

PROVIDER: S-EPMC3985922 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

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Ligand-controlled asymmetric arylation of aliphatic α-amino anion equivalents.

Zhu Ye Y Buchwald Stephen L SL

Journal of the American Chemical Society 20140313 12

A palladium-catalyzed asymmetric arylation of 9-aminofluorene-derived imines using a chiral dialkylbiaryl phosphine as the supporting ligand has been developed. This transformation allows for enantioselective access to a diverse range of α-branched benzylamines. ...[more]

PMID: 24621247

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