Brain microvascular endothelial cells resist elongation due to curvature and shear stress.
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ABSTRACT:
SUBMITTER: Ye M
PROVIDER: S-EPMC3986701 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Publications
Brain microvascular endothelial cells resist elongation due to curvature and shear stress.
Ye Mao M Sanchez Henry M HM Hultz Margot M Yang Zhen Z Bogorad Max M Wong Andrew D AD Searson Peter C PC
Scientific reports 20140415
The highly specialized endothelial cells in brain capillaries are a key component of the blood-brain barrier, forming a network of tight junctions that almost completely block paracellular transport. In contrast to vascular endothelial cells in other organs, we show that brain microvascular endothelial cells resist elongation in response to curvature and shear stress. Since the tight junction network is defined by endothelial cell morphology, these results suggest that there may be an evolutiona ...[more]
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2023-02-17 | PXD036260 | Pride