Ontology highlight
ABSTRACT:
SUBMITTER: Zhou L
PROVIDER: S-EPMC3989693 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Zhou Linli L Tian Xiaoying X Zhu Cailei C Wang Fangwei F Higgins Jonathan M G JM
EMBO reports 20140110 3
Histone modifications coordinate the chromatin localization of key regulatory factors in mitosis. For example, mitotic phosphorylation of Histone H3 threonine-3 (H3T3ph) by Haspin creates a binding site for the chromosomal passenger complex (CPC). However, how these histone modifications are spatiotemporally controlled during the cell cycle is unclear. Here we show that Plk1 binds to Haspin in a Cdk1-phosphorylation-dependent manner. Reducing Plk1 activity decreases the phosphorylation of Haspin ...[more]