Ontology highlight
ABSTRACT:
SUBMITTER: Ha GH
PROVIDER: S-EPMC3263489 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Ha G-H GH Kim H-S HS Go H H Lee H H Seimiya H H Chung D H DH Lee C-W CW
Cell death and differentiation 20110805 2
Telomere length is critical for chromosome stability that affects cell proliferation and survival. Telomere elongation by telomerase is inhibited by the telomeric protein, TRF1. Tankyrase-1 (TNKS1) poly(ADP-ribosyl)ates TRF1 and releases TRF1 from telomeres, thereby allowing access of telomerase to the telomeres. TNKS1-mediated poly(ADP-ribosyl)ation also appears to be crucial for regulating the mitotic cell cycle. In searching for proteins that interact with polo-like kinase-1 (Plk1) by using c ...[more]