Ontology highlight
ABSTRACT:
SUBMITTER: Yonova IM
PROVIDER: S-EPMC3991427 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Yonova Ivelina M IM Johnson A George AG Osborne Charlotte A CA Moore Curtis E CE Morrissette Naomi S NS Jarvo Elizabeth R ER
Angewandte Chemie (International ed. in English) 20140129 9
Alkyl Grignard reagents that contain β-hydrogen atoms were used in a stereospecific nickel-catalyzed cross-coupling reaction to form C(sp(3))-C(sp(3)) bonds. Aryl Grignard reagents were also utilized to synthesize 1,1-diarylalkanes. Several compounds synthesized by this method exhibited selective inhibition of proliferation of MCF-7 breast cancer cells. ...[more]