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Stereospecific nickel-catalyzed cross-coupling reactions of alkyl Grignard reagents and identification of selective anti-breast-cancer agents.

ABSTRACT: Alkyl Grignard reagents that contain ?-hydrogen atoms were used in a stereospecific nickel-catalyzed cross-coupling reaction to form C(sp(3))-C(sp(3)) bonds. Aryl Grignard reagents were also utilized to synthesize 1,1-diarylalkanes. Several compounds synthesized by this method exhibited selective inhibition of proliferation of MCF-7 breast cancer cells.

SUBMITTER: Yonova IM 

PROVIDER: S-EPMC3991427 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

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Stereospecific nickel-catalyzed cross-coupling reactions of alkyl Grignard reagents and identification of selective anti-breast-cancer agents.

Yonova Ivelina M IM   Johnson A George AG   Osborne Charlotte A CA   Moore Curtis E CE   Morrissette Naomi S NS   Jarvo Elizabeth R ER  

Angewandte Chemie (International ed. in English) 20140129 9

Alkyl Grignard reagents that contain β-hydrogen atoms were used in a stereospecific nickel-catalyzed cross-coupling reaction to form C(sp(3))-C(sp(3)) bonds. Aryl Grignard reagents were also utilized to synthesize 1,1-diarylalkanes. Several compounds synthesized by this method exhibited selective inhibition of proliferation of MCF-7 breast cancer cells. ...[more]

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