Ontology highlight
ABSTRACT:
SUBMITTER: Dawson DD
PROVIDER: S-EPMC4955521 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Dawson David D DD Jarvo Elizabeth R ER
Organic process research & development 20150911 10
In this manuscript we highlight the potential of stereospecific nickel-catalyzed cross-coupling reactions for applications in the pharmaceutical industry. Using an inexpensive and sustainable nickel catalyst, we report a gram-scale Kumada cross-coupling reaction. Reactions are highly stereospecific and proceed with inversion at the benzylic position. We also expand the scope of our reaction to incorporate isotopically labeled substituents. ...[more]