Unknown

Dataset Information

0

Stereospecific Nickel-Catalyzed Cross-Coupling Reactions of Benzylic Ethers with Isotopically-Labeled Grignard Reagents.


ABSTRACT: In this manuscript we highlight the potential of stereospecific nickel-catalyzed cross-coupling reactions for applications in the pharmaceutical industry. Using an inexpensive and sustainable nickel catalyst, we report a gram-scale Kumada cross-coupling reaction. Reactions are highly stereospecific and proceed with inversion at the benzylic position. We also expand the scope of our reaction to incorporate isotopically labeled substituents.

SUBMITTER: Dawson DD 

PROVIDER: S-EPMC4955521 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

Stereospecific Nickel-Catalyzed Cross-Coupling Reactions of Benzylic Ethers with Isotopically-Labeled Grignard Reagents.

Dawson David D DD   Jarvo Elizabeth R ER  

Organic process research & development 20150911 10


In this manuscript we highlight the potential of stereospecific nickel-catalyzed cross-coupling reactions for applications in the pharmaceutical industry. Using an inexpensive and sustainable nickel catalyst, we report a gram-scale Kumada cross-coupling reaction. Reactions are highly stereospecific and proceed with inversion at the benzylic position. We also expand the scope of our reaction to incorporate isotopically labeled substituents. ...[more]

Similar Datasets

| S-EPMC3991427 | biostudies-literature
| S-EPMC6631569 | biostudies-literature
| S-EPMC7872209 | biostudies-literature
| S-EPMC8512530 | biostudies-literature
| S-EPMC10717501 | biostudies-literature
| S-EPMC3913001 | biostudies-literature
| S-EPMC5903371 | biostudies-literature
| S-EPMC4980256 | biostudies-literature
| S-EPMC4809423 | biostudies-literature
| S-EPMC8518087 | biostudies-literature