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Palladium-Catalyzed Cross-Coupling of Monochlorosilanes And Grignard Reagents.

ABSTRACT: Using a palladium catalyst supported by DrewPhos, the alkylation of monochlorosilanes with primary and secondary alkyl-magnesium halides is now possible. Arylation with sterically demanding aromatic magnesium halides is also enabled. This transformation overcomes the high bond strength of the Si-Cl bond (113 kcal/mol) and is a rare example of a transition-metal catalyzed process involving its activation. Due to the availability of both chlorosilanes and organomagnesium halide reagents, this method allows for the preparation of a wide range of alkyl and aryl silanes.

SUBMITTER: Vulovic B 

PROVIDER: S-EPMC5984048 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Palladium-Catalyzed Cross-Coupling of Monochlorosilanes And Grignard Reagents.

Vulovic Bojan B   Cinderella Andrew P AP   Watson Donald A DA  

ACS catalysis 20171030 12

Using a palladium catalyst supported by DrewPhos, the alkylation of monochlorosilanes with primary and secondary alkyl-magnesium halides is now possible. Arylation with sterically demanding aromatic magnesium halides is also enabled. This transformation overcomes the high bond strength of the Si-Cl bond (113 kcal/mol) and is a rare example of a transition-metal catalyzed process involving its activation. Due to the availability of both chlorosilanes and organomagnesium halide reagents, this meth  ...[more]

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