Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen QT
PROVIDER: S-EPMC3992257 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Nature neuroscience 20091213 1
Tools from molecular biology, combined with in vivo optical imaging techniques, provide new mechanisms for noninvasively observing brain processes. Current approaches primarily probe cell-based variables, such as cytosolic calcium or membrane potential, but not cell-to-cell signaling. We devised cell-based neurotransmitter fluorescent engineered reporters (CNiFERs) to address this challenge and monitor in situ neurotransmitter receptor activation. CNiFERs are cultured cells that are engineered t ...[more]