Ontology highlight
ABSTRACT:
SUBMITTER: Yamane-Sando Y
PROVIDER: S-EPMC3996568 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Yamane-Sando Yukari Y Shimobayashi Etsuko E Shimobayashi Mitsugu M Kozutsumi Yasunori Y Oka Shogo S Takematsu Hiromu H
MicrobiologyOpen 20140210 2
Sphingolipids are a family of eukaryotic lipids biosynthesized from sphingoid long-chain bases (LCBs). Sphingolipids are an essential class of lipids, as their depletion results in cell death. However, acute LCB supplementation is also toxic; thus, proper cellular LCB levels should be maintained. To characterize the "sphingolipid-signaling intercross," we performed a kinome screening assay in which budding yeast protein kinase-knockout strains were screened for resistance to ISP-1, a potent inhi ...[more]