Ontology highlight
ABSTRACT:
SUBMITTER: Ali F
PROVIDER: S-EPMC6946708 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Ali Farhan F Gerhard Danielle M DM Sweasy Katherine K Pothula Santosh S Pittenger Christopher C Duman Ronald S RS Kwan Alex C AC
Nature communications 20200107 1
A subanesthetic dose of ketamine causes acute psychotomimetic symptoms and sustained antidepressant effects. In prefrontal cortex, the prevailing disinhibition hypothesis posits that N-methyl-d-aspartate receptor (NMDAR) antagonists such as ketamine act preferentially on GABAergic neurons. However, cortical interneurons are heterogeneous. In particular, somatostatin-expressing (SST) interneurons selectively inhibit dendrites and regulate synaptic inputs, yet their response to systemic NMDAR anta ...[more]