Ontology highlight
ABSTRACT:
SUBMITTER: Wang H
PROVIDER: S-EPMC3996831 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Wang Haopeng H Flach Henrik H Onizawa Michio M Wei Lai L McManus Michael T MT Weiss Arthur A
Nature immunology 20140309 4
The microRNA miR-210 is a signature of hypoxia. We found robust increase in the abundance of miR-210 (>100-fold) in activated T cells, especially in the TH17 lineage of helper T cells. Hypoxia acted in synergy with stimulation via the T cell antigen receptor (TCR) and coreceptor CD28 to accelerate and increase Mir210 expression. Mir210 was directly regulated by HIF-1α, a key transcriptional regulator of TH17 polarization. Unexpectedly, we identified Hif1a as a target of miR-210, which suggested ...[more]