Ontology highlight
ABSTRACT:
SUBMITTER: Keller KE
PROVIDER: S-EPMC4000728 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Keller Kirstie E KE Doctor Zainab M ZM Dwyer Zachary W ZW Lee Young-Sam YS
Molecular cell 20140301 5
Abnormal metabolism and sustained proliferation are hallmarks of cancer. Pyruvate kinase M2 (PKM2) is a metabolic enzyme that plays important roles in both processes. Recently, PKM2 was shown to have protein kinase activity phosphorylating histone H3 and promoting cancer cell proliferation. However, the mechanism and extent of this protein kinase in cancer cells remain unclear. Here, we report that binding of succinyl-5-aminoimidazole-4-carboxamide-1-ribose-5'-phosphate (SAICAR), a metabolite ab ...[more]