Ontology highlight
ABSTRACT:
SUBMITTER: Duivenvoorden R
PROVIDER: S-EPMC4001802 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Duivenvoorden Raphaël R Tang Jun J Cormode David P DP Mieszawska Aneta J AJ Izquierdo-Garcia David D Ozcan Canturk C Otten Maarten J MJ Zaidi Neeha N Lobatto Mark E ME van Rijs Sarian M SM Priem Bram B Kuan Emma L EL Martel Catherine C Hewing Bernd B Sager Hendrik H Nahrendorf Matthias M Randolph Gwendalyn J GJ Stroes Erik S G ES Fuster Valentin V Fisher Edward A EA Fayad Zahi A ZA Mulder Willem J M WJ
Nature communications 20140101
Inflammation is a key feature of atherosclerosis and a target for therapy. Statins have potent anti-inflammatory properties but these cannot be fully exploited with oral statin therapy due to low systemic bioavailability. Here we present an injectable reconstituted high-density lipoprotein (rHDL) nanoparticle carrier vehicle that delivers statins to atherosclerotic plaques. We demonstrate the anti-inflammatory effect of statin-rHDL in vitro and show that this effect is mediated through the inhib ...[more]