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Decarboxylative arylation of ?-amino acids via photoredox catalysis: a one-step conversion of biomass to drug pharmacophore.

ABSTRACT: The direct decarboxylative arylation of ?-amino acids has been achieved via visible light-mediated photoredox catalysis. This method offers rapid entry to prevalent benzylic amine architectures from an abundant biomass, specifically ?-amino acid precursors. Significant substrate scope is observed with respect to both the amino acid and arene components.

SUBMITTER: Zuo Z

PROVIDER: S-EPMC4004246 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature

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Decarboxylative arylation of α-amino acids via photoredox catalysis: a one-step conversion of biomass to drug pharmacophore.

Zuo Zhiwei Z MacMillan David W C DW

Journal of the American Chemical Society 20140331 14

The direct decarboxylative arylation of α-amino acids has been achieved via visible light-mediated photoredox catalysis. This method offers rapid entry to prevalent benzylic amine architectures from an abundant biomass, specifically α-amino acid precursors. Significant substrate scope is observed with respect to both the amino acid and arene components. ...[more]

PMID: 24712922

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