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Histone chaperones in nucleosome assembly and human disease.

ABSTRACT: Nucleosome assembly following DNA replication, DNA repair and gene transcription is critical for the maintenance of genome stability and epigenetic information. Nucleosomes are assembled by replication-coupled or replication-independent pathways with the aid of histone chaperone proteins. How these different nucleosome assembly pathways are regulated remains relatively unclear. Recent studies have provided insight into the mechanisms and the roles of histone chaperones in regulating nucleosome assembly. Alterations or mutations in factors involved in nucleosome assembly have also been implicated in cancer and other human diseases. This review highlights the recent progress and outlines future challenges in the field.

SUBMITTER: Burgess RJ

PROVIDER: S-EPMC4004355 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature

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Histone chaperones in nucleosome assembly and human disease.

Burgess Rebecca J RJ Zhang Zhiguo Z

Nature structural & molecular biology 20130101 1

Nucleosome assembly following DNA replication, DNA repair and gene transcription is critical for the maintenance of genome stability and epigenetic information. Nucleosomes are assembled by replication-coupled or replication-independent pathways with the aid of histone chaperone proteins. How these different nucleosome assembly pathways are regulated remains relatively unclear. Recent studies have provided insight into the mechanisms and the roles of histone chaperones in regulating nucleosome a ...[more]

PMID: 23288364

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