Ontology highlight
ABSTRACT:
SUBMITTER: Chaulk SG
PROVIDER: S-EPMC4005684 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Chaulk Steven G SG Xu Zhizhong Z Glover Mark J N MJ Fahlman Richard P RP
Nucleic acids research 20140211 8
While functional mature microRNAs (miRNAs) are small ∼22 base oligonucleotides that target specific mRNAs, miRNAs are initially expressed as long transcripts (pri-miRNAs) that undergo sequential processing to yield the mature miRNAs. We have previously reported that the pri-miR-17∼92 cluster adopts a compact globular folded structure that internalizes a 3' core domain resulting in reduced miRNA maturation and subsequent mRNA targeting. Using a site-specific photo-cross-linker we have identified ...[more]