Ontology highlight
ABSTRACT:
SUBMITTER: Newton K
PROVIDER: S-EPMC4005920 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Newton Kim K Hildebrand Joanne M JM Shen Zhirong Z Rodriguez Diego D Alvarez-Diaz Silvia S Petersen Sean S Shah Saumil S Dugger Debra L DL Huang Chunzi C Auwerx Johan J Vandenabeele Peter P Green Douglas R DR Ashkenazi Avi A Dixit Vishva M VM Kaiser William J WJ Strasser Andreas A Degterev Alexei A Silke John J
Nature 20140201 7489
Sirtuins can promote deacetylation of a wide range of substrates in diverse cellular compartments and regulate many cellular processes¹,². Recently Narayan et al., reported that SIRT2 was required for necroptosis based on their findings that SIRT2 inhibition, knock-down or knock-out prevented necroptosis. We sought to confirm and explore the role of SIRT2 in necroptosis and tested four different sources of the SIRT2 inhibitor AGK2, three independent siRNAs against SIRT2, and cells from two indep ...[more]