Ontology highlight
ABSTRACT:
SUBMITTER: Spaccarotella E
PROVIDER: S-EPMC4007939 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Spaccarotella Elisa E Pellegrino Elisa E Ferracin Manuela M Ferreri Cristina C Cuccuru Giuditta G Liu Cuiling C Iqbal Javeed J Cantarella Daniela D Taulli Riccardo R Provero Paolo P Di Cunto Ferdinando F Medico Enzo E Negrini Massimo M Chan Wing C WC Inghirami Giorgio G Piva Roberto R
Haematologica 20130823 1
Systemic anaplastic large cell lymphoma is a category of T-cell non-Hodgkin's lymphoma which can be further subdivided into two distinct entities (ALK(+) and ALK(-)) based on the presence or absence of ALK gene rearrangements. Among several pathways triggered by ALK signaling, constitutive activation of STAT3 is strictly required for ALK-mediated transformation and survival. Here we performed genome-wide microRNA profiling and identified 48 microRNA concordantly modulated by the inducible knock- ...[more]