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The genetic incorporation of thirteen novel non-canonical amino acids.

ABSTRACT: Thirteen novel non-canonical amino acids were synthesized and tested for suppression of an amber codon using a mutant pyrrolysyl-tRNA synthetase-tRNA(Pyl)(CUA) pair. Suppression was observed with varied efficiencies. One non-canonical amino acid in particular contains an azide that can be applied for site-selective protein labeling.

SUBMITTER: Tuley A 

PROVIDER: S-EPMC4011397 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

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The genetic incorporation of thirteen novel non-canonical amino acids.

Tuley Alfred A   Wang Yane-Shih YS   Fang Xinqiang X   Kurra Yadagiri Y   Rezenom Yohannes H YH   Liu Wenshe R WR  

Chemical communications (Cambridge, England) 20140301 20

Thirteen novel non-canonical amino acids were synthesized and tested for suppression of an amber codon using a mutant pyrrolysyl-tRNA synthetase-tRNA(Pyl)(CUA) pair. Suppression was observed with varied efficiencies. One non-canonical amino acid in particular contains an azide that can be applied for site-selective protein labeling. ...[more]

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