Dataset Information

Tirasemtiv amplifies skeletal muscle response to nerve activation in humans.

ABSTRACT:

Introduction

In this study we tested the hypothesis that tirasemtiv, a selective fast skeletal muscle troponin activator that sensitizes the sarcomere to calcium, could amplify the response of muscle to neuromuscular input in humans.

Methods

Healthy men received tirasemtiv and placebo in a randomized, double-blind, 4-period, crossover design. The deep fibular nerve was stimulated transcutaneously to activate the tibialis anterior muscle and produce dorsiflexion of the foot. The force-frequency relationship of tibialis anterior dorsiflexion was assessed after dosing.

Results

Tirasemtiv increased force produced by the tibialis anterior in a dose-, concentration-, and frequency-dependent manner with the largest increases [up to 24.5% (SE 3.1), P < 0.0001] produced at subtetanic nerve stimulation frequencies (10 Hz).

Conclusions

The data confirm that tirasemtiv amplifies the response of skeletal muscle to nerve input in humans. This outcome provides support for further studies of tirasemtiv as a potential therapy in conditions marked by diminished neuromuscular input.

SUBMITTER: Hansen R

PROVIDER: S-EPMC4260123 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

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Publications

Tirasemtiv amplifies skeletal muscle response to nerve activation in humans.

Hansen Richard R Saikali Khalil G KG Chou Willis W Russell Alan J AJ Chen Michael M MM Vijayakumar Vipin V Stoltz Randall R RR Baudry Stephane S Enoka Roger M RM Morgans David J DJ Wolff Andrew A AA Malik Fady I FI

Muscle & nerve 20141201 6

<h4>Introduction</h4>In this study we tested the hypothesis that tirasemtiv, a selective fast skeletal muscle troponin activator that sensitizes the sarcomere to calcium, could amplify the response of muscle to neuromuscular input in humans.<h4>Methods</h4>Healthy men received tirasemtiv and placebo in a randomized, double-blind, 4-period, crossover design. The deep fibular nerve was stimulated transcutaneously to activate the tibialis anterior muscle and produce dorsiflexion of the foot. The fo ...[more]

PMID: 24634285

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Dataset Information

Tirasemtiv amplifies skeletal muscle response to nerve activation in humans.

Introduction

Methods

Results

Conclusions

Publications

Tirasemtiv amplifies skeletal muscle response to nerve activation in humans.

Similar Datasets

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