Linear superposition and prediction of bacterial promoter activity dynamics in complex conditions.
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ABSTRACT:
SUBMITTER: Rothschild D
PROVIDER: S-EPMC4014397 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Publications
Linear superposition and prediction of bacterial promoter activity dynamics in complex conditions.
Rothschild Daphna D Dekel Erez E Hausser Jean J Bren Anat A Aidelberg Guy G Szekely Pablo P Alon Uri U
PLoS computational biology 20140508 5
Bacteria often face complex environments. We asked how gene expression in complex conditions relates to expression in simpler conditions. To address this, we obtained accurate promoter activity dynamical measurements on 94 genes in E. coli in environments made up of all possible combinations of four nutrients and stresses. We find that the dynamics across conditions is well described by two principal component curves specific to each promoter. As a result, the promoter activity dynamics in a com ...[more]
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