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Towards a facile and convenient synthesis of highly functionalized indole derivatives based on multi-component reactions.

ABSTRACT: A library of potentially bioactive compounds through the novel 1H-indole-methyl-isocyanide and MCRs has been described. A flexible and efficient synthesis affording great complexity and diversity is achieved with moderate to good yields with no need for protection and deprotection steps.

SUBMITTER: Neochoritis CG 

PROVIDER: S-EPMC4015188 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

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Towards a facile and convenient synthesis of highly functionalized indole derivatives based on multi-component reactions.

Neochoritis Constantinos G CG   Dömling Alexander A  

Organic & biomolecular chemistry 20140301 10

A library of potentially bioactive compounds through the novel 1H-indole-methyl-isocyanide and MCRs has been described. A flexible and efficient synthesis affording great complexity and diversity is achieved with moderate to good yields with no need for protection and deprotection steps. ...[more]

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