Ontology highlight
ABSTRACT:
SUBMITTER: Lovett-Barron M
PROVIDER: S-EPMC4018419 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Lovett-Barron Matthew M Kaifosh Patrick P Kheirbek Mazen A MA Danielson Nathan N Zaremba Jeffrey D JD Reardon Thomas R TR Turi Gergely F GF Hen René R Zemelman Boris V BV Losonczy Attila A
Science (New York, N.Y.) 20140201 6173
Fear memories guide adaptive behavior in contexts associated with aversive events. The hippocampus forms a neural representation of the context that predicts aversive events. Representations of context incorporate multisensory features of the environment, but must somehow exclude sensory features of the aversive event itself. We investigated this selectivity using cell type-specific imaging and inactivation in hippocampal area CA1 of behaving mice. Aversive stimuli activated CA1 dendrite-targeti ...[more]