Ontology highlight
ABSTRACT:
SUBMITTER: Mousavizadeh R
PROVIDER: S-EPMC4019633 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Mousavizadeh Rouhollah R Khosravi Shahram S Behzad Hayedeh H McCormack Robert G RG Duronio Vincent V Scott Alex A
PloS one 20140513 5
Angiogenesis is associated with the tissue changes underlying chronic overuse tendinopathy. We hypothesized that repetitive, cyclic loading of human tendon cells would lead to increased expression and activity of angiogenic factors. We subjected isolated human tendon cells to overuse tensile loading using an in vitro model (1 Hz, 10% equibiaxial strain). We found that mechanically stimulated human tendon cells released factors that promoted in vitro proliferation and tube formation by human umbi ...[more]